{"id":337278,"date":"2026-05-31T07:00:00","date_gmt":"2026-05-31T05:00:00","guid":{"rendered":"https:\/\/legrandcontinent.eu\/fr\/?p=337278"},"modified":"2026-05-30T21:53:07","modified_gmt":"2026-05-30T19:53:07","slug":"un-nouveau-modele-dia-a-predit-la-structure-de-plus-dun-milliard-de-proteines","status":"publish","type":"post","link":"https:\/\/legrandcontinent.eu\/fr\/2026\/05\/31\/un-nouveau-modele-dia-a-predit-la-structure-de-plus-dun-milliard-de-proteines\/","title":{"rendered":"Un nouveau mod\u00e8le d\u2019IA a pr\u00e9dit la structure de plus d\u2019un milliard de prot\u00e9ines"},"content":{"rendered":"\n<p>Les prot\u00e9ines assurent des fonctions essentielles dans l\u2019organisme&#160;: elles transportent les nutriments dans le corps, participent au syst\u00e8me immunitaire, \u00e0 la circulation sanguine, \u00e0 la contraction des muscles\u2026 Conna\u00eetre leur structure permet de mieux comprendre le fonctionnement des maladies, et contribue ainsi au d\u00e9veloppement de m\u00e9dicaments.<\/p>\n\n\n\n<p>Il y a quelques ann\u00e9es, nous ne connaissions que quelques dizaines de milliers de structures sur les 2 milliards existantes estim\u00e9es. Un nouvel outil d\u2019IA vient d\u2019en cartographier plus d\u2019un milliard&nbsp;<span class='whitespace-nowrap'><span id='easy-footnote-1-337278' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote note-digits-1'><a href='https:\/\/legrandcontinent.eu\/fr\/2026\/05\/31\/un-nouveau-modele-dia-a-predit-la-structure-de-plus-dun-milliard-de-proteines\/#easy-footnote-bottom-1-337278' title='&lt;a href=&quot;https:\/\/biohub.ai\/esm\/protein\/atlas&quot;&gt;ESM Atlas&lt;\/a&gt;, Biohub.'><sup>1<\/sup><\/a><\/span><\/span>.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Avant l\u2019intelligence artificielle, la pr\u00e9diction de la structure des prot\u00e9ines reposait surtout sur la cristallographie aux rayons X, une m\u00e9thode fastidieuse et co\u00fbteuse mise au point au d\u00e9but du XXe si\u00e8cle.<\/li>\n\n\n\n<li>Le lancement en 2018 d\u2019<a href=\"https:\/\/legrandcontinent.eu\/fr\/2025\/07\/08\/google-veut-tester-ses-premiers-medicaments-concus-par-ia-sur-des-humains\/\">AlphaFold<\/a>, un programme d\u2019IA d\u00e9velopp\u00e9 par Google DeepMind, a r\u00e9volutionn\u00e9 le champ en permettant en 2020 de pr\u00e9dire la structure des 200 millions de prot\u00e9ines identifi\u00e9es par les chercheurs.<\/li>\n\n\n\n<li>Les pr\u00e9c\u00e9dentes m\u00e9thodes avaient permis l\u2019identification d\u2019environ 170 000 prot\u00e9ines en 60 ans&nbsp;<span class='whitespace-nowrap'><span id='easy-footnote-2-337278' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote note-digits-1'><a href='https:\/\/legrandcontinent.eu\/fr\/2026\/05\/31\/un-nouveau-modele-dia-a-predit-la-structure-de-plus-dun-milliard-de-proteines\/#easy-footnote-bottom-2-337278' title='Robert F. Service, \u00ab&amp;#160;&lt;a href=&quot;https:\/\/www.science.org\/content\/article\/game-has-changed-ai-triumphs-solving-protein-structures&quot;&gt;\u2018The game has changed.&amp;rsquo; AI triumphs at solving protein structures&lt;\/a&gt;&amp;#160;\u00bb, &lt;em&gt;Science&lt;\/em&gt;, 30 novembre 2020.'><sup>2<\/sup><\/a><\/span><\/span>.<\/li>\n<\/ul>\n\n\n\n<div class=\"iframe-container wp-block-image wp-block-image-medium  iframe-dw\">\n\t<div>\n\t\t<iframe class=\"absolute w-full h-full pin-t pin-l\" title=\"titolo\" aria-label=\"Interactive line chart\" src=\"\/\/datawrapper.dwcdn.net\/t86UH\/\" scrolling=\"no\" frameborder=\"0\"><\/iframe>\n\t<\/div>\n<\/div>\n\n\n\n<p>Mercredi 27 mai, des chercheurs de la Chan Zuckerberg Initiative, un institut biom\u00e9dical cr\u00e9\u00e9 par Mark Zuckerberg et Priscilla Chan, ont d\u00e9voil\u00e9 une nouvelle base de donn\u00e9es, ESM Atlas, qui contient plus d&rsquo;un milliard de structures prot\u00e9iques et plusieurs milliards de s\u00e9quences prot\u00e9iques suppl\u00e9mentaires. Elle surpasse ainsi la base de donn\u00e9es d\u2019AlphaFold d\u2019environ 800 millions de structures, et un pr\u00e9c\u00e9dent ESM Atlas d\u2019environ 300 millions.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Les chercheurs \u00e0 l\u2019origine de la base de donn\u00e9es affirment que l\u2019atlas \u00ab&#160;a pour fonction de montrer la totalit\u00e9 de la biologie des prot\u00e9ines, et en particulier les parties les plus m\u00e9connues&#160;\u00bb.<\/li>\n\n\n\n<li>Ils revendiquent avoir utilis\u00e9 le mod\u00e8le d\u2019IA ESMFold2 pour concevoir de nouveaux anticorps et des prot\u00e9ines capables de se lier \u00e0 d\u2019autres prot\u00e9ines impliqu\u00e9es dans des cancers et des troubles immunologiques&nbsp;<span class='whitespace-nowrap'><span id='easy-footnote-3-337278' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote note-digits-1'><a href='https:\/\/legrandcontinent.eu\/fr\/2026\/05\/31\/un-nouveau-modele-dia-a-predit-la-structure-de-plus-dun-milliard-de-proteines\/#easy-footnote-bottom-3-337278' title='Ewen Callaway et Miryam Naddaf, \u00ab&amp;#160;&lt;a href=&quot;https:\/\/www.nature.com\/articles\/d41586-026-01686-3&quot;&gt;Move over, AlphaFold&amp;#160;: open-source model predicts shape of 1 billion proteins&lt;\/a&gt;&amp;#160;\u00bb, &lt;em&gt;Nature&lt;\/em&gt;, 27 mai 2026.'><sup>3<\/sup><\/a><\/span><\/span>.<\/li>\n\n\n\n<li>Une grande partie des conceptions test\u00e9es en laboratoire auraient fonctionn\u00e9&nbsp;<span class='whitespace-nowrap'><span id='easy-footnote-4-337278' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote note-digits-1'><a href='https:\/\/legrandcontinent.eu\/fr\/2026\/05\/31\/un-nouveau-modele-dia-a-predit-la-structure-de-plus-dun-milliard-de-proteines\/#easy-footnote-bottom-4-337278' title='Salvatore Candido &lt;em&gt;et. al&lt;\/em&gt;., \u00ab&amp;#160;&lt;a href=&quot;https:\/\/bhp-papers-prod.s3.us-west-2.amazonaws.com\/esm_protein.pdf?X-Amz-Algorithm=AWS4-HMAC-SHA256&amp;amp;X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&amp;amp;X-Amz-Credential=ASIAU6GD3FYNJP4TMJOE%2F20260530%2Fus-west-2%2Fs3%2Faws4_request&amp;amp;X-Amz-Date=20260530T035518Z&amp;amp;X-Amz-Expires=3600&amp;amp;X-Amz-Security-Token=IQoJb3JpZ2luX2VjEAwaCXVzLXdlc3QtMiJHMEUCIQDA6TSP9U9%2B0q623%2FUxAwpHphf1Y%2FgTqMAvnRRuRpWoNAIgGnx7WPAJH%2FVxQbAH9%2BP7bLLn%2B1bijzXG%2BdC%2FMIPeJ80qsgUI1f%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FARAAGgwzMzk3MTMxNDIyOTgiDL4lv2BBAulXadQY%2FiqGBT9Nqbn7D0GeP%2FI7xnGZyZhPa%2B43Apb1gh91zQc1cCHRmU7B5XMkWL46E2SrUHATOUTiZzcd%2FKeLkDkRi3X7Tl3ZzOnE%2FWXb%2BXujLpyyOgL72kM8Zlf3QHz2CuCRN8q5MjO0TqBsgFiUuHNMp4ngMs%2F8XCW4jn4NplQ2nj6qpuKk9yQmbpayR3S%2FeAVHv3e6xLVv2NS1IBrpiZsXhtMQSGHkzTtAr47SAOJ7lgqb8u4DfLkUTECD7R%2FSxSUXD9jwHyNkyHYNPQGPLBVP3Ac6w8bnYg%2Fez3ixG%2BjOuILeFIuvB4iZWohj4uZDZtJ8J%2BoV3YO2K47Hp4NuH1r8r366OsGebelFnf%2FPxp84%2Bl3iKEo7NedF083mMc7h2XDAc2pTj7nBqsoJakBCJbQWY0QAKxRilby4Uiu6C5LoPXqvVL6kzzjeBJ04r0Zyx8Kru7nMZjedX9sbZrp%2FTIXhEBiQWPpWnvWb0raW0KbktfGMLBzlAeXraAb4kJfTpbsr%2Bm52A1vAKMRlUozuRXmm2jBq4J1GtM8xJCN1%2FhkkwIjZZ5AJzwTdngNmCyqTwzBfxnQKOodBJ%2BVDHXmspj7tWtQRScHPdQeP89cZXdL7mFlYrCD2EN3fJf6nB0%2BGb0RNQnsvTxm6dJf5EgQhKiH93Kx%2Bjio2w5oIJ86DdjotJZCyomaFdN5IjBjSiyaw0b%2Fp4x6ByRkPXd4WjqKN85eH2M47EA9y%2B%2FP4IZ3zWstxreb2hgdGu7sw8QoJXtvQ5NHW7n3OUolS77AvpquD6NkK7NjQvi96A%2B1ctLsDWz6eDgKHUlyYkujAfsgaN2r2jNx4rHaZ6muh4tEuy%2BniB1r0b9alpAPoDCnbRJQwhrLp0AY6mQH2SWYR%2FUC3s0o6JV96xubof50O3yESTJVo7bBLxa63QvnaA9znhnbNZwJLnJbC5GSrwZqC97nNitCL6ITVwZ3XJob0%2BCcm7y6tMqw49BoUQqmxM3Ic%2BZ2thmc0yDrHbL4sfh1ZBVQ78toQzMRlM7TvIPCk1oaq0amyf4A3TzpyosrDWw5VG7BmsPVeD%2BZ0GuX0ewJdEezwpLY%3D&amp;amp;X-Amz-Signature=03a896eece0fac9e8101112fa78188a438dbcbbe11c786c22fbc9213c5b946cc&amp;amp;X-Amz-SignedHeaders=host&amp;amp;x-amz-checksum-mode=ENABLED&amp;amp;x-id=GetObject&quot;&gt;Language Modeling Materializes a World Model of Protein Biology&lt;\/a&gt;&amp;#160;\u00bb, 27 mai 2026.'><sup>4<\/sup><\/a><\/span><\/span>.<\/li>\n<\/ul>\n\n\n\n<div class=\"iframe-container wp-block-image wp-block-image-medium  iframe-dw\">\n\t<div>\n\t\t<iframe class=\"absolute w-full h-full pin-t pin-l\" title=\"titolo\" aria-label=\"Interactive line chart\" src=\"\/\/datawrapper.dwcdn.net\/8zVkK\/\" scrolling=\"no\" frameborder=\"0\"><\/iframe>\n\t<\/div>\n<\/div>\n\n\n\n<p>L\u2019utilisation de l\u2019intelligence artificielle par les chercheurs pourrait permettre d\u2019acc\u00e9l\u00e9rer consid\u00e9rablement la mise sur le march\u00e9 de nouveaux m\u00e9dicaments, de r\u00e9duire les co\u00fbts et d\u2019am\u00e9liorer les probabilit\u00e9s de succ\u00e8s clinique.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Avant les premiers mod\u00e8les d\u2019intelligence artificielle, les m\u00e9thodes de recherche existantes avaient permis l\u2019identification d\u2019environ 170 000 prot\u00e9ines en 60 ans.<\/p>\n","protected":false},"author":40,"featured_media":337280,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"templates\/post-briefings.php","format":"standard","meta":{"_acf_changed":true,"_trash_the_other_posts":false,"_yoast_wpseo_estimated-reading-time-minutes":3,"footnotes":""},"categories":[2210],"tags":[],"staff":[],"editorial_format":[4942],"serie":[],"audience":[],"geo":[2163],"class_list":["post-337278","post","type-post","status-publish","format-standard","hentry","category-sante-publique","editorial_format-actu-breves","geo-monde"],"acf":{"open_in_webview":false,"accent":"default","_thumbnail_id":337280,"excerpt":"Avant les premiers mod\u00e8les d\u2019intelligence artificielle, les m\u00e9thodes de recherche existantes avaient permis l\u2019identification d\u2019environ 170 000 prot\u00e9ines en 60 ans.\r\n","display_date":"","new_abstract":true},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin 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