{"id":100927,"date":"2026-05-31T07:00:00","date_gmt":"2026-05-31T05:00:00","guid":{"rendered":"https:\/\/legrandcontinent.eu\/es\/?p=100927"},"modified":"2026-05-30T22:52:00","modified_gmt":"2026-05-30T20:52:00","slug":"nuevo-modelo-ia-ha-predicho-estructura-de-mil-millones-de-proteinas","status":"publish","type":"post","link":"https:\/\/legrandcontinent.eu\/es\/2026\/05\/31\/nuevo-modelo-ia-ha-predicho-estructura-de-mil-millones-de-proteinas\/","title":{"rendered":"Un nuevo modelo de IA ha predicho la estructura de m\u00e1s de mil millones de prote\u00ednas"},"content":{"rendered":"\n<p>Las prote\u00ednas desempe\u00f1an funciones esenciales en el organismo: transportan nutrientes por el cuerpo, intervienen en el sistema inmunitario, en la circulaci\u00f3n sangu\u00ednea, en la contracci\u00f3n muscular\u2026 Conocer su estructura permite comprender mejor el funcionamiento de las enfermedades y contribuye as\u00ed al desarrollo de medicamentos.<\/p>\n\n\n\n<p>Hace unos a\u00f1os, s\u00f3lo conoc\u00edamos unas pocas decenas de miles de estructuras de los 2.000 millones que se calcula que existen. Una nueva herramienta de IA acaba de cartografiar m\u00e1s de mil millones&nbsp;<span class='whitespace-nowrap'><span id='easy-footnote-1-100927' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote note-digits-1'><a href='https:\/\/legrandcontinent.eu\/es\/2026\/05\/31\/nuevo-modelo-ia-ha-predicho-estructura-de-mil-millones-de-proteinas\/#easy-footnote-bottom-1-100927' title='&lt;a href=&quot;https:\/\/biohub.ai\/esm\/protein\/atlas&quot;&gt;ESM Atlas&lt;\/a&gt;, Biohub.'><sup>1<\/sup><\/a><\/span><\/span>.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Antes de la inteligencia artificial, la predicci\u00f3n de la estructura de las prote\u00ednas se basaba principalmente en la cristalograf\u00eda de rayos X, un m\u00e9todo laborioso y costoso desarrollado a principios del siglo XX.<\/li>\n\n\n\n<li>El lanzamiento en 2018 de <a href=\"https:\/\/legrandcontinent.eu\/es\/2025\/07\/08\/google-quiere-probar-en-humanos-sus-primeros-medicamentos-disenados-por-ia\/\">AlphaFold<\/a>, un programa de inteligencia artificial desarrollado por Google DeepMind, revolucion\u00f3 el campo al permitir, en 2020, predecir la estructura de los 200 millones de prote\u00ednas identificadas por los investigadores.<\/li>\n\n\n\n<li>Los m\u00e9todos anteriores hab\u00edan permitido identificar unas 170.000 prote\u00ednas en 60 a\u00f1os&nbsp;<span class='whitespace-nowrap'><span id='easy-footnote-2-100927' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote note-digits-1'><a href='https:\/\/legrandcontinent.eu\/es\/2026\/05\/31\/nuevo-modelo-ia-ha-predicho-estructura-de-mil-millones-de-proteinas\/#easy-footnote-bottom-2-100927' title='Robert F. Service, \u00ab\u201c&lt;a href=&quot;https:\/\/www.science.org\/content\/article\/game-has-changed-ai-triumphs-solving-protein-structures&quot;&gt;The game has changed.\u201d AI triumphs at solving protein structures&lt;\/a&gt;\u00bb, &lt;em&gt;Science&lt;\/em&gt;, 30 de noviembre de 2020.'><sup>2<\/sup><\/a><\/span><\/span>.<\/li>\n<\/ul>\n\n\n\n<div class=\"iframe-container wp-block-image wp-block-image-medium  iframe-dw\">\n\t<div>\n\t\t<iframe class=\"absolute w-full h-full pin-t pin-l\" title=\"titolo\" aria-label=\"Interactive line chart\" src=\"\/\/datawrapper.dwcdn.net\/iRCzD\/\" scrolling=\"no\" frameborder=\"0\"><\/iframe>\n\t<\/div>\n<\/div>\n\n\n\n<p>El mi\u00e9rcoles 27 de mayo, investigadores de la Chan Zuckerberg Initiative, un instituto biom\u00e9dico creado por Mark Zuckerberg y Priscilla Chan, presentaron una nueva base de datos, ESM Atlas, que contiene m\u00e1s de mil millones de estructuras proteicas y varios miles de millones de secuencias proteicas adicionales. De este modo, supera a la base de datos de AlphaFold, que cuenta con unos 800 millones de estructuras, y a una versi\u00f3n anterior de ESM Atlas, que ten\u00eda unos 300 millones.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Los investigadores responsables de la base de datos afirman que el atlas \u00abtiene como objetivo mostrar la biolog\u00eda de las prote\u00ednas en su totalidad, y en particular sus aspectos menos conocidos\u00bb.<\/li>\n\n\n\n<li>Afirman haber utilizado el modelo de IA ESMFold2 para dise\u00f1ar nuevos anticuerpos y prote\u00ednas capaces de unirse a otras prote\u00ednas implicadas en c\u00e1nceres y trastornos inmunol\u00f3gicos&nbsp;<span class='whitespace-nowrap'><span id='easy-footnote-3-100927' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote note-digits-1'><a href='https:\/\/legrandcontinent.eu\/es\/2026\/05\/31\/nuevo-modelo-ia-ha-predicho-estructura-de-mil-millones-de-proteinas\/#easy-footnote-bottom-3-100927' title='Ewen Callaway y Miryam Naddaf, \u00ab&lt;a href=&quot;https:\/\/www.nature.com\/articles\/d41586-026-01686-3&quot;&gt;Move over, AlphaFold: open-source model predicts shape of 1 billion proteins&lt;\/a&gt;\u00bb, &lt;em&gt;Nature&lt;\/em&gt;, 27 de mayo de 2026.'><sup>3<\/sup><\/a><\/span><\/span>.<\/li>\n\n\n\n<li>Al parecer, gran parte de los modelos probados en el laboratorio habr\u00edan funcionado&nbsp;<span class='whitespace-nowrap'><span id='easy-footnote-4-100927' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote note-digits-1'><a href='https:\/\/legrandcontinent.eu\/es\/2026\/05\/31\/nuevo-modelo-ia-ha-predicho-estructura-de-mil-millones-de-proteinas\/#easy-footnote-bottom-4-100927' title='Salvatore Candido &lt;em&gt;et al&lt;\/em&gt;., \u00ab&lt;a href=&quot;https:\/\/bhp-papers-prod.s3.us-west-2.amazonaws.com\/esm_protein.pdf?X-Amz-Algorithm=AWS4-HMAC-SHA256&amp;amp;X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&amp;amp;X-Amz-Credential=ASIAU6GD3FYNJP4TMJOE%2F20260530%2Fus-west-2%2Fs3%2Faws4_request&amp;amp;X-Amz-Date=20260530T035518Z&amp;amp;X-Amz-Expires=3600&amp;amp;X-Amz-Security-Token=IQoJb3JpZ2luX2VjEAwaCXVzLXdlc3QtMiJHMEUCIQDA6TSP9U9%2B0q623%2FUxAwpHphf1Y%2FgTqMAvnRRuRpWoNAIgGnx7WPAJH%2FVxQbAH9%2BP7bLLn%2B1bijzXG%2BdC%2FMIPeJ80qsgUI1f%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FARAAGgwzMzk3MTMxNDIyOTgiDL4lv2BBAulXadQY%2FiqGBT9Nqbn7D0GeP%2FI7xnGZyZhPa%2B43Apb1gh91zQc1cCHRmU7B5XMkWL46E2SrUHATOUTiZzcd%2FKeLkDkRi3X7Tl3ZzOnE%2FWXb%2BXujLpyyOgL72kM8Zlf3QHz2CuCRN8q5MjO0TqBsgFiUuHNMp4ngMs%2F8XCW4jn4NplQ2nj6qpuKk9yQmbpayR3S%2FeAVHv3e6xLVv2NS1IBrpiZsXhtMQSGHkzTtAr47SAOJ7lgqb8u4DfLkUTECD7R%2FSxSUXD9jwHyNkyHYNPQGPLBVP3Ac6w8bnYg%2Fez3ixG%2BjOuILeFIuvB4iZWohj4uZDZtJ8J%2BoV3YO2K47Hp4NuH1r8r366OsGebelFnf%2FPxp84%2Bl3iKEo7NedF083mMc7h2XDAc2pTj7nBqsoJakBCJbQWY0QAKxRilby4Uiu6C5LoPXqvVL6kzzjeBJ04r0Zyx8Kru7nMZjedX9sbZrp%2FTIXhEBiQWPpWnvWb0raW0KbktfGMLBzlAeXraAb4kJfTpbsr%2Bm52A1vAKMRlUozuRXmm2jBq4J1GtM8xJCN1%2FhkkwIjZZ5AJzwTdngNmCyqTwzBfxnQKOodBJ%2BVDHXmspj7tWtQRScHPdQeP89cZXdL7mFlYrCD2EN3fJf6nB0%2BGb0RNQnsvTxm6dJf5EgQhKiH93Kx%2Bjio2w5oIJ86DdjotJZCyomaFdN5IjBjSiyaw0b%2Fp4x6ByRkPXd4WjqKN85eH2M47EA9y%2B%2FP4IZ3zWstxreb2hgdGu7sw8QoJXtvQ5NHW7n3OUolS77AvpquD6NkK7NjQvi96A%2B1ctLsDWz6eDgKHUlyYkujAfsgaN2r2jNx4rHaZ6muh4tEuy%2BniB1r0b9alpAPoDCnbRJQwhrLp0AY6mQH2SWYR%2FUC3s0o6JV96xubof50O3yESTJVo7bBLxa63QvnaA9znhnbNZwJLnJbC5GSrwZqC97nNitCL6ITVwZ3XJob0%2BCcm7y6tMqw49BoUQqmxM3Ic%2BZ2thmc0yDrHbL4sfh1ZBVQ78toQzMRlM7TvIPCk1oaq0amyf4A3TzpyosrDWw5VG7BmsPVeD%2BZ0GuX0ewJdEezwpLY%3D&amp;amp;X-Amz-Signature=03a896eece0fac9e8101112fa78188a438dbcbbe11c786c22fbc9213c5b946cc&amp;amp;X-Amz-SignedHeaders=host&amp;amp;x-amz-checksum-mode=ENABLED&amp;amp;x-id=GetObject&quot;&gt;Language Modeling Materializes a World Model of Protein Biology&lt;\/a&gt;\u00bb, 27 de mayo de 2026.'><sup>4<\/sup><\/a><\/span><\/span>.<\/li>\n<\/ul>\n\n\n\n<div class=\"iframe-container wp-block-image wp-block-image-medium  iframe-dw\">\n\t<div>\n\t\t<iframe class=\"absolute w-full h-full pin-t pin-l\" title=\"titolo\" aria-label=\"Interactive line chart\" src=\"\/\/datawrapper.dwcdn.net\/CGcUe\/\" scrolling=\"no\" frameborder=\"0\"><\/iframe>\n\t<\/div>\n<\/div>\n\n\n\n<p>El uso de la inteligencia artificial por parte de los investigadores podr\u00eda acelerar considerablemente la comercializaci\u00f3n de nuevos medicamentos, reducir los costes y mejorar las probabilidades de \u00e9xito cl\u00ednico.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Antes de los primeros modelos de inteligencia artificial, los m\u00e9todos de b\u00fasqueda existentes hab\u00edan identificado unas 170.000 prote\u00ednas en 60 a\u00f1os.<\/p>\n","protected":false},"author":40,"featured_media":100902,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"templates\/post-briefings.php","format":"standard","meta":{"_acf_changed":true,"_trash_the_other_posts":false,"_yoast_wpseo_estimated-reading-time-minutes":3,"footnotes":""},"categories":[174],"tags":[],"staff":[],"editorial_format":[1472],"serie":[],"audience":[],"geo":[198],"class_list":["post-100927","post","type-post","status-publish","format-standard","hentry","category-salud-publica","editorial_format-analisis","geo-mundo"],"acf":{"open_in_webview":false,"accent":"default","_thumbnail_id":100902,"excerpt":"Antes de los primeros modelos de inteligencia artificial, los m\u00e9todos de b\u00fasqueda existentes hab\u00edan identificado unas 170.000 prote\u00ednas en 60 a\u00f1os.\r\n","display_date":"","new_abstract":true},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - 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